tag:blogger.com,1999:blog-4833628955058077617.post7850347930403295925..comments2024-02-20T16:22:10.042-05:00Comments on Tuit Nutrition: Metabolic Theory of Cancer: Glycolysis Run Amok & Mutant HexokinaseAmy B.http://www.blogger.com/profile/08471580967464668110noreply@blogger.comBlogger16125tag:blogger.com,1999:blog-4833628955058077617.post-7899287357318958142018-07-06T09:59:20.059-04:002018-07-06T09:59:20.059-04:00Hi Amy,
As soon as I read your description of HK2 ...Hi Amy,<br />As soon as I read your description of HK2 as "mutant" I knew what the source of this was. <br />I wrote to Travis Christofferson about this but didn't receive a reply.<br />HK2 is only aberrant in HK4-dominant (glucokinase) tissues, and there are very few of these -- mainly the endocrine pancreas and the liver. That is because these organs functionally require the "sensing" of blood glucose levels. <br />HK2 is the dominant hexokinase expressed in muscle tissue, and its behavior in attaching to the VDAC is NORMAL in myocytes for example. This should be unsurprising, since high power (i.e. rapid ATP generation) is often required in muscle, and this is accomplished by fermentation to lactate rather than respiration which is VO2-limited. <br />Peter Pedersen did indeed first discover this behavior of HK2 in liver, which is the tissue he focuses upon in his cancer research. But it is only unusual primarily in liver -- not necessarily in other human tissues. It is a normal human hexokinase highly expressed in some tissues. <br />HK4 has a much higher Km than the other human hexokinases, and is completely inappropriate for high-power requiring tissues such as muscle:<br />https://en.wikipedia.org/wiki/Hexokinase<br />So any type of human cell which is differentiated to have significant anaerobic ATP generation requirements normally (some of the time), and concurrently has no need for glucose sensing, will express HK1/2/3 predominantly.<br />In a liver tumor, the malignant cell has abnormally developed this same requirement for its survival (due to damaged respiration/mitochondria), and adapted to mimic what is normal behavior in other organs. Since all of the cells are differentiated from the same genetic code (i.e. stem cells) this should not be surprising. It merely requires the turning on and turning off, or upregulation and downregulation, of various genes present in all of our cells, including hexokinase II. <br />Kenhttps://www.blogger.com/profile/15001751821787672311noreply@blogger.comtag:blogger.com,1999:blog-4833628955058077617.post-63842483312357787202017-12-27T16:26:07.080-05:002017-12-27T16:26:07.080-05:00I agree with Tim, Amy xxI agree with Tim, Amy xxJudy Dnoreply@blogger.comtag:blogger.com,1999:blog-4833628955058077617.post-14051406378213625152016-01-19T00:12:08.765-05:002016-01-19T00:12:08.765-05:00My guess would be HK2 or its progenitors is upregu...My guess would be HK2 or its progenitors is upregulated in accordance with the ancestral DNA encoding for it, kind of like rebooting after a disc error so you can pick an earlier version.<br />The energy stress imposed on the cell would force selection for it and somehow unlock the encoding, otherwise the cell would die. Timhttps://www.blogger.com/profile/16566361944570795169noreply@blogger.comtag:blogger.com,1999:blog-4833628955058077617.post-72473563805104718102016-01-18T23:55:06.920-05:002016-01-18T23:55:06.920-05:00This might be one of the nicest comments I've ...This might be one of the nicest comments I've ever received! Thank you, truly.Tuit Nutritionhttps://www.blogger.com/profile/15708859914305178756noreply@blogger.comtag:blogger.com,1999:blog-4833628955058077617.post-42000464534719505302016-01-18T23:49:22.717-05:002016-01-18T23:49:22.717-05:00Amy the great thing here is the ordinary person ca...Amy the great thing here is the ordinary person can interact with it, can think about it and truly understand, perhaps for the first time. The professionals use buzzwords and psycho-babble to keep the commoners out. You are like Robin Hood, you take from the rich and give to the poor.<br />My hat is off.Timhttps://www.blogger.com/profile/16566361944570795169noreply@blogger.comtag:blogger.com,1999:blog-4833628955058077617.post-75497765654055423752016-01-18T23:44:10.688-05:002016-01-18T23:44:10.688-05:00So when OxPhos fails the cell goes back to ferment...So when OxPhos fails the cell goes back to fermentation. How does it know what to do?<br />Where is the plan? The answer seems to be the cell encodes ALL information back to the year dot in its DNA. <br />So the plans for fermentaion are still there, just waiting to be unlocked. This is beautiful. Nature builds on top of, does not destroy.Timhttps://www.blogger.com/profile/16566361944570795169noreply@blogger.comtag:blogger.com,1999:blog-4833628955058077617.post-55051272089633875052016-01-18T23:27:56.462-05:002016-01-18T23:27:56.462-05:00Don't lose heart. You are doing the good thing...Don't lose heart. You are doing the good thing. The truth about cancer (if it is the truth and I hope so) is better than almond cookies. This is refreshing Amy.<br />Timhttps://www.blogger.com/profile/16566361944570795169noreply@blogger.comtag:blogger.com,1999:blog-4833628955058077617.post-42076152454968727422015-12-04T12:02:20.336-05:002015-12-04T12:02:20.336-05:00Hehheh...glad you found me!Hehheh...glad you found me!Tuit Nutritionhttps://www.blogger.com/profile/15708859914305178756noreply@blogger.comtag:blogger.com,1999:blog-4833628955058077617.post-45095295273850264132015-12-04T07:03:50.180-05:002015-12-04T07:03:50.180-05:00Finding all your blogs tucked away is like being o...Finding all your blogs tucked away is like being on an Easter egg hunt with plenty of eggs lying around all overBryanhttp://www.pantarbe.co.zanoreply@blogger.comtag:blogger.com,1999:blog-4833628955058077617.post-81100886335131631872015-01-17T10:55:08.341-05:002015-01-17T10:55:08.341-05:00:-) Well, I'm sorry I'm keeping you up la...:-) Well, I'm sorry I'm keeping you up late, but it's for a good cause, right? Thanks for reading!Tuit Nutritionhttps://www.blogger.com/profile/15708859914305178756noreply@blogger.comtag:blogger.com,1999:blog-4833628955058077617.post-12465751154016957862015-01-17T10:54:03.234-05:002015-01-17T10:54:03.234-05:00Thanks so much, Marc! Really appreciate the positi...Thanks so much, Marc! Really appreciate the positive feedback. Glad more people are starting to find this. Tuit Nutritionhttps://www.blogger.com/profile/15708859914305178756noreply@blogger.comtag:blogger.com,1999:blog-4833628955058077617.post-70904052000802993642015-01-16T22:48:01.638-05:002015-01-16T22:48:01.638-05:00Another fantastic post - please keep them coming. ...Another fantastic post - please keep them coming. Thank you so much for doing this! Marc Rouleauhttps://www.blogger.com/profile/01988211651936994568noreply@blogger.comtag:blogger.com,1999:blog-4833628955058077617.post-61628657168855990172015-01-07T23:35:01.334-05:002015-01-07T23:35:01.334-05:00I've read Christofferson's book and your w...I've read Christofferson's book and your work expands on it nicely. Keep up the great posts. I have a newly diagnosed low grade lymphoma so am reading everything I can about the metabolic approach and ketogenic diets. At the least that should be a nice adjunct to standard treatment.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-4833628955058077617.post-9196968223321081782015-01-03T05:21:01.918-05:002015-01-03T05:21:01.918-05:00Amy, this is great stuff. Please keep it coming. ...Amy, this is great stuff. Please keep it coming. It is so rewarding to actually understand the processes going on in the body and to then relate that what I put in my mouth, how much of it goes in, and what I do with my body (movement & exercise). Very empowering information, and I am ever so grateful to you for presenting it the way you do. The evenings when your posts arrive in my in-box are the only time I break my rule of "no screens on after 8pm". Now I'll be late to bed!!Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-4833628955058077617.post-6436213360215731162015-01-02T20:46:08.407-05:002015-01-02T20:46:08.407-05:00Wow, nice work Amy! I need to make time to read Ch...Wow, nice work Amy! I need to make time to read Christofferson's book. And I look forward to your next post.Anonymoushttps://www.blogger.com/profile/15581765308131905910noreply@blogger.comtag:blogger.com,1999:blog-4833628955058077617.post-3672764707697850912015-01-02T19:46:57.275-05:002015-01-02T19:46:57.275-05:00Enjoying your trip down the metabolic pathway.
Goo...Enjoying your trip down the metabolic pathway.<br />Good stuff. Keep it coming.<br />Anonymousnoreply@blogger.com