tag:blogger.com,1999:blog-4833628955058077617.post3095423451629517361..comments2024-02-20T16:22:10.042-05:00Comments on Tuit Nutrition: ITIS -- It's the Insulin, Stupid (pt 6/8)Amy B.http://www.blogger.com/profile/08471580967464668110noreply@blogger.comBlogger28125tag:blogger.com,1999:blog-4833628955058077617.post-14421451330592809282016-05-10T21:59:59.782-04:002016-05-10T21:59:59.782-04:00I spent about 3 yrs as a navigator on the KC-135 b...I spent about 3 yrs as a navigator on the KC-135 before going to pilot training. I was a pilot on the KC-10 (tanker and airlift) and also did some time as a instructor pilot for new pilots in the T-1; 3 years in beautiful Del Rio, TX :-)<br /><br />And I spent about 7 years at Scott AFB working in the TACC - Tanker Airlift Control Center. Nathanhttps://www.blogger.com/profile/08671418246991333854noreply@blogger.comtag:blogger.com,1999:blog-4833628955058077617.post-46460509252117816422016-05-10T16:42:50.792-04:002016-05-10T16:42:50.792-04:00BTW -- what did you fly? (I was an airborne lingui...BTW -- what did you fly? (I was an airborne linguist...Rivet Joint/RC-135, but we worked in many other [smaller] platforms in Iraq.)Tuit Nutritionhttps://www.blogger.com/profile/15708859914305178756noreply@blogger.comtag:blogger.com,1999:blog-4833628955058077617.post-84523904325702276632016-05-10T16:41:42.025-04:002016-05-10T16:41:42.025-04:00Nobody takes issue with BMI more than I do! (Hence...Nobody takes issue with BMI more than I do! (Hence why I write about it so much and so forcefully.) I literally starved myself down to my "max weight" to pass the MEPS before going to basic training. It was *ridiculous,* because I had run a friggin' marathon and worked out a ton, so it's not exactly like I was out of shape. (If anything, that was my final wakeup call that exercise is NOT really all that great for fat loss. For cardiovascular conditioning, sure, but not for improving body comp.) Don't even get me started. The funny thing is, the military as a whole, I think, is starting to see that the country's dietary guidelines are GARBAGE, because there are so few young kids who meet the standards anymore, be it for weight or fitness. When so many millions of *kids* are overweight or obese, even the people who are conventional all the way have to start questioning what the heck is going on.<br /><br />I really liked some aspects of the military, but there are others that I don't miss for a second. Dumbass rules about height & weight charts are certainly one. ;-)<br /><br />Thanks for reading!Tuit Nutritionhttps://www.blogger.com/profile/15708859914305178756noreply@blogger.comtag:blogger.com,1999:blog-4833628955058077617.post-43281634652029546202016-05-08T10:18:25.600-04:002016-05-08T10:18:25.600-04:00Regarding BMI, this has been a peeve of mine for a...Regarding BMI, this has been a peeve of mine for a long time. I was in the Air Force too, and when I was at Officer Training School in '86 I was badgered about my weight. I was 5' 9.5" 190ish and quite lean and muscular. But they blindly looked at their height vs. weight charts (essentially BMI in a slightly different form) and told me I needed to lose some weight. I was a bit flabbergasted, to say the least.<br /><br />That continued when I got to navigator training a few months later. I had to bite my tongue as I stood in front of my squadron commander in my blues being told that I needed to lose weight, despite very obviously being very fit. He lectured me about how I should become a runner like him. Hated that guy. I did drop a few pounds as a result of not doing much weight lifting, so I kept them off my back. But it was my first look at a blind and stupid bureaucracy, and some pinheads like that commander who enabled it. <br /><br />They (the bureaucrats in the Pentagon) got better about it later in my career, as I'm sure you're aware of with your time in service. (I eventually went thru pilot training and retired as an O-5, after about 22 years.)<br /><br />Someone finally opened their eyes to the obvious and realized that some folks didn't fit the mold and should be tested for actual body composition instead being berated for being "overweight"; duh. In the meantime a lot of good people had to tell folks like me that there was nothing they could do about the rules even though they were beyond stupid (I was one of them later; ugh). I'm sure that some even got drummed out for their ostensible overweight condition. Although there were also a lot of actually overweight senior officers and NCOs who weren't affected. Gotta love that fair and even treatment and universality of rules, eh?<br /><br />Anyway, that always hits a nerve with me, if you couldn't tell. :-) <br /><br />Love your blog and I'm still working my way thru (and I still have to read your AD book, which is on my Kindle, waiting for me). Keep up the great work.Nathanhttps://www.blogger.com/profile/08671418246991333854noreply@blogger.comtag:blogger.com,1999:blog-4833628955058077617.post-85249489621437422292015-11-07T19:15:45.370-05:002015-11-07T19:15:45.370-05:00Thanks for reading! The learning is absolutely end...Thanks for reading! The learning is absolutely endless. I know very little about leptin & adiponectin. When you have even the smallest appreciation for how complex this all is, "eat less, move more" and "calories in, calories out" become almost laughably simplistic and inadequate. Tuit Nutritionhttps://www.blogger.com/profile/15708859914305178756noreply@blogger.comtag:blogger.com,1999:blog-4833628955058077617.post-40825853649114185432015-11-07T16:42:24.141-05:002015-11-07T16:42:24.141-05:00Strong work Amy. The answer lies between the comm...Strong work Amy. The answer lies between the communication signals of adiponectin and leptin. Look there and you'll see what I've been seeing for 10 years.Adam Nally, DOhttps://www.blogger.com/profile/09337764607883423817noreply@blogger.comtag:blogger.com,1999:blog-4833628955058077617.post-4865858797058690402015-11-06T05:16:54.613-05:002015-11-06T05:16:54.613-05:00I'm not a physician, just a diabetic looking t...I'm not a physician, just a diabetic looking to learn more about our disease, and there's lots to learn. Someone gave me a link to this and I tell people the same thing on my site and I've been trying to wake people up to this for quite a while now. This isn't a popular view of course, the idea that the conventional approach to diabetes has it so wrong. A lot of diabetics seem to have some real limitations on how far outside the box they will go, they may say well these people are clueless where it comes to diet but aside from that they are doctors so they must otherwise know what they are doing. I've never had that problem though :)<br /><br />I haven't read the last 2 parts yet but I am looking forward to it, I came back here to see if they were up yet. <br /><br />Without peeking, I think that while diet can obviously be very helpful, it of course doesn't get at the root of the problem, although it can limit the damage. So there are some positive changes that we can make, the usual lifestyle things, and with some of us that may be enough, although this is still a managed state and not necessarily a resolved one. When we compare diabetics with non diabetics though on the same diet there are some things that are wrong here and it's not the usual suspects, it's a disease of hormonal imbalance and there's definitely more to it than just the excess of the pancreatic hormones, or we'd be cured when we just normalize them for a while.<br /><br />I do horribly on low carb by the way and let me tell you that's made things more challenging and interesting, so when diet doesn't help and there's no way I'm touching any of their meds, well you're pretty much left to your own resources. So it's not that my diet is unrestricted but strangely enough I ended up back to what I was eating when my A1C was in the 11's, which I actually do best on now in conjunction with the stuff I take, so that's as close as taking diet right out of the picture as you can get I guess :)<br /><br />So getting back to the real pathology, this really comes down to controlling hepatic glucose production and glucagon obviously plays a big part in that, I think leptin resistance is big as well and we know what happens from that, leptin also regulates glucagon, there's lots left to think about that's for sure :) I've also had some success with things that increase AMPK, in particular with berberine and gynostemma, working on controlling lipogenesis, I think that bergamot is great for this by the way, along with the bunch of other things I take. Keep up the great work and it takes a lot to impress me but this really has :)<br />Anonymoushttps://www.blogger.com/profile/15076210478376807986noreply@blogger.comtag:blogger.com,1999:blog-4833628955058077617.post-51604349778738513072015-11-01T21:22:59.223-05:002015-11-01T21:22:59.223-05:00Thanks, Ann! Page views have dropped dramatically ...Thanks, Ann! Page views have dropped dramatically between the first post and number six here, so it's nice to know there are still people out there reading it and finding it helpful. :)Tuit Nutritionhttps://www.blogger.com/profile/15708859914305178756noreply@blogger.comtag:blogger.com,1999:blog-4833628955058077617.post-65337676535813677892015-11-01T17:14:48.667-05:002015-11-01T17:14:48.667-05:00Love these posts! Ty for writing! If I hadn't ...Love these posts! Ty for writing! If I hadn't started reading and thinking, I'm sure I would be dead by now. Truly no exaggeration. New book out by Doug McGuff called Primal Prescription (foreword by MSission) is an awesome read and helps explain why there are so few doctors willing and able to investigate and recommend new protocols. Thank God for the Internet and smart, caring and generous writers such as yourself. Xo. AnnAnonymousnoreply@blogger.comtag:blogger.com,1999:blog-4833628955058077617.post-40789729266655462292015-11-01T13:51:35.702-05:002015-11-01T13:51:35.702-05:00Thanks for the insightful comments, Ken. Are you a...Thanks for the insightful comments, Ken. Are you a physician? You sound like one. (And a knowledgeable one, at that.) You are correct -- parts 7 & 8 haven't been posted yet. Still writing them. ;-) Part 7 is still looking at body weight/body fat regulation in relation to insulin, but the 8th and final installment will address what you've mentioned here -- the *other* interventions that are likely necessary to correct/reverse insulin resistance, besides just a low-carb diet and possibly fasting/reducing feeding frequency. There's a lot more to it than that. It would be nice if it were as simple as going to a LCHF diet, wouldn't it? And that works very well for many people out there. Some don't even need to go full-on low-carb, but can very impressively improve & normalize their blood markers simply by adopting a Paleo or Primal diet, but not one that is expressly very low in carbohydrate. Other people need a multi-pronged approach, depending on the severity and complexity of their IR.Tuit Nutritionhttps://www.blogger.com/profile/15708859914305178756noreply@blogger.comtag:blogger.com,1999:blog-4833628955058077617.post-29168900041301949832015-11-01T03:07:01.453-05:002015-11-01T03:07:01.453-05:00Well I made it this far and I am very impressed. ...Well I made it this far and I am very impressed. I had to find my own way to 6 by the way and 7 and 8 don't seem to be up but this an excellent presentation.<br /><br />I actually eat just one full meal a day and one snack and have found that regimen to be by far the best approach for me. We eat way too habitually and it's also very habit forming, if the body gets accustomed to a certain amount of feedings it will coerce you, or rather the hormones that drive this will :)<br /><br />T2 is really all about broken signaling and you have done a nice job looking at the two main influencers here, insulin and glucagon. I feel that diabetes comes down to just one of them though, glucagon. We owe a huge debt to Roger Unger here, I've referred to him on my site as the Einstein of diabetes research, and I don't feel that's an exaggeration. We would probably still be in the dark ages if not for his breakthrough work, although come to think of it just about everyone is indeed stuck back in the dark ages, at least when it comes to the practice of treating this disease. They prefer the dark though as too much light exposes their ineptitude.<br /><br />The big question from here is, what do we do about this? I brought this up in a comment earlier but now that we're at least getting to the end, it does need to be asked. This is way bigger than just being handicapped as far as glucose tolerance goes. We know that's just a symptom not a cause. I'm all for dietary management but at the same time we can't fool ourselves into thinking this is a solution, it's just a compensatory mechanism, in spite of it often being a necessary one.<br /><br />I've moved away from focusing on insulin so much over the last while, especially lately, glucagon is obviously the problem and excess insulin clearly plays a big role in its over secretion over time, and especially its role in lipogenesis and lipotoxicity. So reducing insulin is needed, but we also need to repair the damage so to speak, and also address other issues that may be going on, other means of broken signaling. I think fat plays a big role in this, especially the accumulation of fat in cells, we crow with pride when we can clear some glucose out of the blood but don't realize that this actually does harm, but what's even more significant is the fact that insulin drives both fat and glucose into the blood.<br /><br />So the two damaging mechanisms here are, guess what, glucotoxicity and lipotoxicity. We're back to excess insulin now with a vengeance, but again, reducing the insult is just part of it. <br /><br />Conventional medicine on the other hand just wants to escalate our insulin toxicity, good night! <br /><br />Anyway this comment is long enough, thanks for the very good article and thanks for helping spread the truth about all of this! :)Anonymoushttps://www.blogger.com/profile/15076210478376807986noreply@blogger.comtag:blogger.com,1999:blog-4833628955058077617.post-36750965770389728172015-10-30T08:24:24.447-04:002015-10-30T08:24:24.447-04:00Whn my mother was young there were no "epidem...Whn my mother was young there were no "epidemics" of obesity or diabetes (or a lot of other conditions) and "everyone knew" that to lose weight you cut starches, and that diabetics ate a low carb diet.<br /><br />This was still true when I was young. I'm realising now that when my generation dies out there will be no-one left who remembers a time when low fat was NOT standard operating procedure.<br /><br />One of our doctors was the size of a small building. She told me patronisingly that "everyone has to eat carbs or you have no energy" and that "diabetes in always progressive, it's the nature of the disease!" <br /><br />Strangely when she discovered she was "prediabetic" she decided to lose weight. I had hoped she had discovered low carb but no, she was doing 5:2. Anything to keep shovelling those "essential" carbs down her neck. Obvuously she had diabetes in situ for years.<br /><br />The doctor who is a "diabetes specialist" told me she expected that by now I would be fully diabetic and on "at least two" drugs. Many (most?) diabetics are told to eat a low fat diet and expect to be on insulin within five - ten years. Since ACCORD many well controlled diabetics are told to "stop it at once" and increase their A1c, and many doctors now deregister their diabetics, even Type 1s on occasion, if they achieve A1c below 6%.<br /><br />Quote from a nurse "if you test your blood you will damage your fingers and then you won't be able to read Braille when you go blind!" There's just soooo much wrong with that statement I don't know where to start!<br /><br />Most dieticians here are overweight too. Yet they give Malhotra no end of stick. His main job is fixing their mistakes! Soon perhaps he will be operating on them.<br /><br />I see things moving in both directions at once. There are thousands of patients making huge improvements in their health - but there need to be MILLIONS to make a difference. There are probably now several dozen clueful doctors and dieticians - but there need to be thousands. There's an increasing mountain of evidence on PubMed, not a little of which backs up and develops stuff that was known in the past and since ignored - but it is concealed from doctors by what is ironically called "Evidence Based Medicine". Currently it looks as if The Establishment is fighting back - after all telling people to eat the most profitable diet and then prescribing the most profitable drugs as an antidote is a Big Win for everyone, except the patients.<br /><br />All power to you and the other bloggers for your work in disseminating Clue.chris cnoreply@blogger.comtag:blogger.com,1999:blog-4833628955058077617.post-79376434067250710122015-10-29T18:12:10.052-04:002015-10-29T18:12:10.052-04:00Haha, yes, all the "anecdotes!" I love ...Haha, yes, all the "anecdotes!" I love Malhotra -- he seems to be getting far more mainstream press in the UK than any LCHF researchers and MDs ever get in the US. There are so many people who think they're "eating right" or think they'll be protected because they're following doctor's orders, but then how come they just get sicker and sicker? (If not more and more overweight?)<br /><br />Thanks for all the great comments, Chris! Glad you're liking these posts.Tuit Nutritionhttps://www.blogger.com/profile/15708859914305178756noreply@blogger.comtag:blogger.com,1999:blog-4833628955058077617.post-12833195605860274902015-10-29T18:05:53.621-04:002015-10-29T18:05:53.621-04:00Oh my gosh, Chris...sounds like you've been th...Oh my gosh, Chris...sounds like you've been through the wringer! Good on you for finding LCHF and "correcting" things on your own. It's really a shame how ignorant many healthcare providers are. These are the "experts" we trust to steer us in the right direction, and sadly, so many of them are absolutely *clueless* when it comes to the very basics about human physiology and metabolism. That's why I try to write my blog in an educational way -- translate the textbook stuff into plain English we can all understand and make sense of. Because when we understand how the human body actually works, the types of foods we should be eating is fairly easy to understand. Maybe it's still difficult to pass up the donuts and cheesecake, but at least we understand the physiological consequences if we choose to indulge.<br /><br />It's madness what you went through -- especially with the dietitian! When it comes to getting ourselves well and *staying* that way to the best of our individual bodies' capacity, we're largely on our own. Conventional doctors and nutritionists have completely missed the boat.Tuit Nutritionhttps://www.blogger.com/profile/15708859914305178756noreply@blogger.comtag:blogger.com,1999:blog-4833628955058077617.post-46836591944731574502015-10-29T18:00:13.268-04:002015-10-29T18:00:13.268-04:00EXACTLY.EXACTLY.Tuit Nutritionhttps://www.blogger.com/profile/15708859914305178756noreply@blogger.comtag:blogger.com,1999:blog-4833628955058077617.post-60272806721084852802015-10-29T13:56:29.179-04:002015-10-29T13:56:29.179-04:00part 3
I have maintained this for over a decade ...part 3<br /><br /><br />I have maintained this for over a decade now. As a result I have now been told there was never anything wrong with me. Thus cognitive dissonance is not engaged. I have no doubt I could have done this any time in the previous five decades, which was WHY I was never told how to achieve it, and nor were any of my relatives. After all "everyone knows" that diabetes is caused by being fat, and being fat is caused by eating fat . . . and CVD is caused by "cholesterol" which is also caused by eating fat. Low fat diets are only an abject failure because people fail to adhere to them. Everyone who has the same result as me (or even better) is "just an anecdote" and everyone from you to Ron Krauss and Jeff Volek et al. are just "cranks on the internet". Oh and Aseem Malhotra, the latest in a long line!<br /><br />What is really scary is how totally not alone I am in all this. Worse still when I die (soon) from CVD this will never be blamed on the fifty years of high carb eating, high BG, high insulin, high IR, crap lipids etc. but on the last decade of "not eating enough starch".<br />chris cnoreply@blogger.comtag:blogger.com,1999:blog-4833628955058077617.post-44143986154575976452015-10-29T13:55:55.968-04:002015-10-29T13:55:55.968-04:00part 2
I think IR is an adaptive mechanism for t...part 2<br /><br /><br />I think IR is an adaptive mechanism for the rapid storage of a glut of food - BUT this only works if the IR genes are then switched off so the stored fat can be metabolised. This is what modern "low fat" diets, especially when most of the fats remaining are Omega 6s, fail to do. IR also works at different tissues to partition food, but when it becomes chronic this also fails. <br /><br />In retrospect all my symptoms, going back to early childhood, were symptoms of diabetes and conditions "common in diabetics" but because I was skinny and obviously not Type 1, the decision was made to claim that they were either psychiatric in origin, or completely made up. I have never had a proper Phase 1 insulin response so my postprandial BG leapt up at the 1 hour mark, by which time the Phase 2 insulin had started to come online and knocked it down. By three or four hours the insulin had failed to shut off and my BG went through the floor, causing release not only of glucagon but also cortisol, epinephrine and norepinephrine. Probably IR between the pancreatic alpha and beta cells is a factor. This cycling between hyperglycemia and hypoglycemia with hyperinsulinemia went on most of my life. I've since met a small but significant number of people with the exact same syndrome - Reactive Hypoglycemia - from whom I learned the mechanism. Now doctors are not permitted to diagnose this and anyone who "claims" to suffer from RH must be diagnosed with a "neurotic condition" called Idiopathic Postprandial Syndrome - so doctors now have no knowledge of the mechanism and therefore no clue how to treat the condition. <br /><br />About half these cases have gone on to be diagnosed diabetic: the rest have remained "prediabetic" but IN ALL CASES by acting as if they were already diabetic and eating LCHF they have stopped the progression and reversed most of the symptoms. Hence diabetes in situ.<br /><br />Yet strangely I remained at low normal weight, UNTIL I met a dietician. She was intent on removing every scrap of fat from my diet and replacing it with more carbs, and when this had the expected effect of making my dyslipidemia even worse, raising my BP further and causing me to gain weight I was naturally accused of "failing to comply" with the diet. After all, avoiding cognitive dissonance is far more important than health!<br /><br />Eventually I met a half clueful doctor who gave me a GTT and told me I "just had a touch of prediabetes" - and gave me exactly the same high carb low fat diet I was already desperately trying to follow. I was specifically told that "we" don't like our patients testing their BG. So obviously I went straight out and bought a glucometer.<br /><br />In only a few weeks I had my BG nailed by low carbing, my BP came down significantly, my HDL DOUBLED and my trigs fell to 1/10 of what they were. Obviously the IR went away - trigs/HDL is a good surrogate for IR, CVD risk and also small dense LDL: mine went from nearly 7 to under 1 (UK numbers). Oh and I lost the 15 kg I had gained.<br />chris cnoreply@blogger.comtag:blogger.com,1999:blog-4833628955058077617.post-44431121248478762312015-10-29T13:54:57.458-04:002015-10-29T13:54:57.458-04:00This is an AWESOME series of posts!
I discovered ...This is an AWESOME series of posts!<br /><br />I discovered Joseph Kraft through Ivor Cummin's' interview on The Fat Emperor and realised he is yet another Person Of Clue which doctors have never heard of, along with John Yudkin, Peter Cleave, Weston A Price etc.<br /><br />"Diabetes in situ" exactly describes what happened to me, and a significant number of people in my family.<br /><br />There's a bimodal distribution in one side of the family: my mother lived to be 95, her cousins 88 and 91, her own mother 90. Mostly they die of CVD, basically from being completely worn out.<br /><br />Her brother died at 70 - massive heart attack. One of her uncles was the only known diagnosed diabetic - skinny and poorly controlled even on insulin, he underwent several amputations. Genealogical research has shown a number of other diabetics and a bunch of other people, mainly males, who died young of CVD (also a surprising number of children who, like my siblings, died before or soon after (premature) birth). I have no doubt they were all sufferers of "diabetes in situ".<br /><br />Most interesting is that some of the fatter folks had much better outcomes than us skinnies. My late aunt (88) oh actually my mother's cousin, was told at 80 she had the blood pressure of a 30 year old. When I was 30 I already had the BP of an 80 year old. Her slimmer fitter more active sister was the one who had the gallstones, dyslipidemia, hypertension and other metabolic defects - just like me.<br /><br />I suspect the reason is that the fatties were able to stash their lipids in fat cells, whereas us skinnies left them rattling around in the blood along with the high BG and high insulin. I've seen this variously called Metabolic Obesity, Skinny Fat and even Lipodystrophy Lite.<br />chris cnoreply@blogger.comtag:blogger.com,1999:blog-4833628955058077617.post-14641064651623852722015-10-28T23:57:24.336-04:002015-10-28T23:57:24.336-04:00Thanks, Stuart. I've been having a bad day, an...Thanks, Stuart. I've been having a bad day, and seeing your comment was probably the high point. :)<br />The cancer series has been in full swing since last November. It's been a while since I've added to it, because there were things I was more excited to write about, but I'll get back to it in a few weeks. If you didn't know it was already up and running, you can check out the first post here, and each one ends with a link to the next installment: http://www.tuitnutrition.com/2014/11/metabolic-theory-cancer-intro.htmlTuit Nutritionhttps://www.blogger.com/profile/15708859914305178756noreply@blogger.comtag:blogger.com,1999:blog-4833628955058077617.post-67050969899120714282015-10-28T21:30:12.642-04:002015-10-28T21:30:12.642-04:00Just love the content and style Amy , very much e...Just love the content and style Amy , very much enjoyed the 'ITIS' series and looking forward to the one's on cancer. Anonymoushttps://www.blogger.com/profile/12324667080265171517noreply@blogger.comtag:blogger.com,1999:blog-4833628955058077617.post-56084245130346525982015-10-28T21:21:14.330-04:002015-10-28T21:21:14.330-04:00This comment has been removed by the author.Anonymoushttps://www.blogger.com/profile/12324667080265171517noreply@blogger.comtag:blogger.com,1999:blog-4833628955058077617.post-78502887231188730492015-10-28T14:40:02.477-04:002015-10-28T14:40:02.477-04:00" They are eating a diet rich in carbs and pr..." They are eating a diet rich in carbs and processed foods, yet it has not impacted their lipid profile" Depends on what you consider "impacting" the lipid profile. They may have a lowish total cholesterol and low LDL, but sky high triglycerides and HDL's in the toilet. Most doctors wouldn't bat an eye at that profile, they'd think it's perfectly fine because total and LDL are low. And most patients blindly accept the conventional wisdom. "My doctor says my cholesterol is great." That's all they know. JanKnitzhttps://www.blogger.com/profile/06178703790352191912noreply@blogger.comtag:blogger.com,1999:blog-4833628955058077617.post-6379670882221905062015-10-28T14:36:39.651-04:002015-10-28T14:36:39.651-04:00My daughter would not have been diagnosed if I did...My daughter would not have been diagnosed if I didn't recognize the signs and symptoms. Her doctor was reluctant to test her because she thought that there was no way my thin daughter could have PCOS. When the results came back, she called me personally to tell me I was right. My daughter's testosterone levels were through the roof--higher than my highest high ever was, blood glucose and insulin levels were high for her age and size. The question in my mind is how many other thin girls are NOT diagnosed. They are thrown on BCP's to regulate periods and treat acne, and don't find out there's a real problem until they try to get pregnant a decade later. And my poor daughter had to sit through the first pediatric endocrinologist (who had all the signs of PCOS herself!) telling her that the best way to treat PCOS was to lose weight. I wanted to slug this doctor for suggesting that to a THIN 13 year old--what was she thinking???? It was the only suggestion she had! Another doctor covering for my daughter's pediatrician said "she can't have PCOS, she's thin." How many cases are these Pedi's missing entirely???JanKnitzhttps://www.blogger.com/profile/06178703790352191912noreply@blogger.comtag:blogger.com,1999:blog-4833628955058077617.post-8436850168768818862015-10-28T05:16:20.507-04:002015-10-28T05:16:20.507-04:00I had wondered whether the fat gain is some kind o...I had wondered whether the fat gain is some kind of protection mechanism, so it was good to see you put this subject into words. I've come across overweight people who have no problem with their cholesterol and not on any medications. They are eating a diet rich in carbs and processed foods, yet it has not impacted their lipid profile.<br />It makes me wonder if the skinny on the outside, fat on the inside people are actually suffering because of this lack of protection mechanism, ie elevated levels of insulin will manifest itself in a much more harmful way such as heart disease, kidney damage etc.<br />It would be interesting to do a long term study of "constitutionally thin" people against those who gain fat easily and see if there is a trend in terms of symptoms/blood work changes following a long term high carb/sugar diet.<br />ChrisAnonymousnoreply@blogger.comtag:blogger.com,1999:blog-4833628955058077617.post-64797647310148556272015-10-27T23:45:09.140-04:002015-10-27T23:45:09.140-04:00Thanks for the heads up. Oh, lord. Apparently thes...Thanks for the heads up. Oh, lord. Apparently these people missed the studies that show *higher* cholesterol is protective later in life - not just for Alz, but for all-cause mortality. And that being said, the E4s do seem to get a raw deal no matter what they do. I'm not willing to say for sure that *everyone* (including E4s) benefits from higher cholesterol as they age, but many do. I know one group that benefits from old folks reducing their cholesterol -- statin drug manufacturers. :-/Tuit Nutritionhttps://www.blogger.com/profile/15708859914305178756noreply@blogger.com