(Last updated 25 April 2016 ... Due for a big update April 2017 -- coming soon!)
I have created this page in order to make it easy to find all of my work regarding metabolic and lifestyle strategies to combat Alzheimer’s disease. It will be updated regularly.
The cornerstone of this research is my book, The Alzheimer’s Antidote: Using a Low-Carb, High-Fat Diet to Fight Alzheimer's Disease, Memory Loss, and Cognitive Decline.
Websites & Blogs
I have written about Alzheimer’s disease in magazines, for guest posts on others’ websites, and posts on my own blog:
- An Antidote for Alzheimer’s: Guest post on the blog of Robb Wolf, well-known advocate for “Paleo”-style diets and ancestral health.
- Type 3 Diabetes: Metabolic Causes of Alzheimer’s Disease: A feature article on the dietary and metabolic factors that are believed to underlie Alzheimer’s disease, as well as general guidance on how to reverse them. This was published in the Summer 2014 issue of Wise Traditions, the journal of the Weston A. Price Foundation, which is a non-profit organization dedicated to educating people about nutrient-dense diets, robust physical and mental health, sustainable and humane farming, and in general, the diet and lifestyle practices that kept our ancestors healthy and hardy well into old age, and free of the chronic conditions that afflict so many of us today (such as heart disease, diabetes, metabolic syndrome, obesity, infertility, emotional instability, and more.) Please note: a more detailed version of this article, containing slightly more discussion of biochemical mechanisms, is available via email. Please contact me if you would prefer to read that version.
- A Nutritional Approach to Prevent & Heal Alzheimer’s: A feature article in the Jan/Feb 2016 issue of Well Being Journal. This is a print magazine. You can order a hard copy of the magazine ($6.95 USD plus shipping) or download a pdf ($4.00 USD). This magazine is usually available for sale at larger health food stores and Whole Foods in the U.S. and Canada.
- Alzheimer’s, Ketones, and Kidding Ourselves: A 3-part series in which I explored the pros and cons of employing exogenous ketones as therapy for Alzheimer’s disease.
Beyond my written work, I have been interviewed about nutrition and lifestyle interventions for Alzheimer’s on the following podcasts, all of which can be found on iTunes, or downloaded directly from the links below:
- The Livin’ la Vida Low Carb Show: “The Ketogenic Antidote to Alzheimer’s Disease” (air date 6/15/2015).
- Real World Paleo Podcast: “How You Can Delay Alzheimer’s and Dementia” (air date 11/22/2015)
- Real World Paleo Podcast: “How Ketogenic Diets Work for Many Conditions.” (air date 4/14/2016) *This episode explores ketogenic diets for diverse neurological conditions, including Alzheimer's, but also Parkinson's, ALS, multiple sclerosis, epilepsy, traumatic brain injury, and more.
- The Paleo Solution Podcast: “Nutrition and Alzheimer’s” (air date 9/15/2015). Note: there was some static on my microphone during this show, but you can still hear me clearly.
- Lyme Ninja Radio: “The Alzheimer's Antidote” (air date 12/27/2015)
Scientific & Medical Research
If you would like to explore some of the scientific literature regarding the idea of Alzheimer’s disease as “type 3 diabetes,” and metabolic influences on the pathology and progression of Alzheimer’s, cognitive impairment, cognitive decline, and memory loss, here is a selection of my favorite papers. (In some cases, only the abstract is available, rather than the full text.)
- Nutrition and Alzheimer's disease: The detrimental role of a high carbohydrate diet. Seneff S, Wainwright G, Mascitelli L. Eur J Intern Med. 2011 Apr;22(2):134-40.
- High carbohydrate diets and Alzheimer’s disease. Henderson ST. Med Hypotheses. 2004;62(5):689-700.
- Reversal of cognitive decline: A novel therapeutic program. Bredesen DE. Aging (Albany NY). 2014 Sep;6(9):707-17.
- Brain metabolic dysfunction at the core of Alzheimer’s disease. De la Monte SM, Tong M. Biochemical pharmacology. 2014;88(4):548-559.
- Insulin signaling, glucose metabolism and mitochondria: major players in Alzheimer's disease and diabetes interrelation. Brain Res. Correia SC, Santos RX, Carvalho C et al. 2012 Mar 2;1441:64-78.
- Insulin resistance and Alzheimer’s disease. De la Monte SM. BMB reports. 2009;42(8):475-481.
- Type 3 Diabetes is Sporadic Alzheimer’s disease: Mini-Review. De la Monte SM. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. 2014;24(12):1954-1960.
- Metabolic derangements mediate cognitive impairment and Alzheimer’s disease: role of peripheral insulin resistance diseases. De la Monte SM. Panminerva medica. 2012;54(3):171-178.
- Alzheimer's disease and diabetes: an integrative view of the role of mitochondria, oxidative stress, and insulin. Moreira PI. J Alzheimers Dis. 2012;30 Suppl 2:S199-215.
- The Alzheimer’s Disease Mitochondrial Cascade Hypothesis: Progress and Perspectives. Swerdlow RH, Burns JM, Khan SM. Biochimica et biophysica acta. 2014;1842(8):1219-1231.
- Brain Fuel Metabolism, Aging and Alzheimer’s Disease. Cunnane S, Nugent S, Roy M, et al. Nutrition (Burbank, Los Angeles County, Calif). 2011;27(1):3-20.
- Brain mitochondrial dysfunction as a link between Alzheimer's disease and diabetes. Moreira PI, Santos MS, Seiça R, Oliveira CR. J Neurol Sci. 2007 Jun 15;257(1-2):206-14.
- Insulin resistance and Alzheimer's disease: molecular links & clinical implications. Neumann KF, Rojo L et al. Curr Alzheimer Res. 2008 Oct;5(5):438-47.
- Hyperinsulinemia and risk of Alzheimer disease. Luchsinger JA, Tang MX, Shea S, Mayeux R. Neurology. 2004 Oct 12;63(7):1187-92.
- Hyperinsulinemia and Cognitive Decline in a Middle-Aged Cohort. Young SE, Mainous AG 3rd, Carnemolla M. Diabetes Care. 2006 Dec;29(12):2688-93.
Disclaimer: Amy Berger, M.S., NTP, is not a physician and Tuit Nutrition, LLC, is not a medical practice. The information contained on this site is not intended to diagnose, treat, cure, or prevent any medical condition.