tag:blogger.com,1999:blog-4833628955058077617.post792441777672407040..comments2024-02-20T16:22:10.042-05:00Comments on Tuit Nutrition: The Personal Fat Threshold ConceptAmy B.http://www.blogger.com/profile/08471580967464668110noreply@blogger.comBlogger49125tag:blogger.com,1999:blog-4833628955058077617.post-18036757233856465412021-10-25T16:10:04.798-04:002021-10-25T16:10:04.798-04:00As always people are trying to find a very simple ...As always people are trying to find a very simple explanation for a complex disease like Diabetes. It's now understood that adult humans can grow new fat cells when they over consume energy, which pours cold water on the concept of "personal fat threshold". Particular genetic pathway activations involving the PPAR gamma, "Peroxisome proliferator- activated receptor", make the generation of new subcutaneous fat cells possible under the influence of a high-fat diet. This largely depends on the nature of the diet - that is, that a low carbohydrate, but high fat diet can produce obesity without any risk of metabolic complications relating to diabetes. Most overweight people eat a lot of refined carbohydrates, which tend to produce a higher accumulation of visceral fat, which is what is linked to diabetes. Studies show that expansion of the subcutaneous fat deposits through the activation of PPARgamma under influence of a high fat, lower carb diet can produce metabolically "healthy" obesity.<br /><br />You can even test this on yourself with a blood sugar meter - if you like experimenting with getting fat, that is. Do a diet with vast amounts of saturated fats and gain 30-40lbs (I actually did this) of pure fat - but with low carbs - and measure your blood sugar regularly through the test. You will see your blood sugar is flat line, and doesn't increase or spike. If you, however, gained the same weight on a high carb diet, you'll see large spikes and hyperglycaemic blood sugar levels, as most of your fat gain will be visceral fat.<br /><br />So in truth, there is no overall "personal fat threshold" - the way weight gain influences your risk of diabetes has to do with the type of fat you gain, based on the particular genetic pathway activations influenced by the constitution of the high energy diet. <br /><br />Of course, just because it's possible to get obese without metabolic complications, that doesn't mean it's healthy to do so, and the risk of cardiac complications and other problems still exists.<br /><br />So this, really is another over-simple theory that tries to provide a neat explanation for a complex disease. There are far too many more variables involved in the dysregulation (or not) of metabolic processes under the influence of weight gain and a high energy diet.Richard G Rees-Williamshttps://www.blogger.com/profile/12527719335810650000noreply@blogger.comtag:blogger.com,1999:blog-4833628955058077617.post-33787972008886852312021-09-19T15:56:57.558-04:002021-09-19T15:56:57.558-04:00OMG!!! This is just what I've been looking fo...OMG!!! This is just what I've been looking for, and so much more! Thank you, Amy!!!Flamingo999https://www.blogger.com/profile/04562759427453978983noreply@blogger.comtag:blogger.com,1999:blog-4833628955058077617.post-82079694714826417362021-05-16T22:22:18.921-04:002021-05-16T22:22:18.921-04:00Excellent, thank youExcellent, thank youAnonymousnoreply@blogger.comtag:blogger.com,1999:blog-4833628955058077617.post-13614901394090609472021-01-01T11:14:10.172-05:002021-01-01T11:14:10.172-05:00Possible it isn't type two but rather some var...Possible it isn't type two but rather some variant of adult onset type 1.Andiehttps://www.blogger.com/profile/05471435347207157647noreply@blogger.comtag:blogger.com,1999:blog-4833628955058077617.post-43116069519357366762020-07-10T05:15:19.362-04:002020-07-10T05:15:19.362-04:00Thanks for this. One thing that bothered me was yo...Thanks for this. One thing that bothered me was your attitude towards your marathon-runner body. The foods you ate and the body composition you had worked PERFECTLY to achieve a massive feat! You ran a marathon! And I think we really ought to celebrate our victories and the fantastic work or bodies to to get us there. Randi Cecchinehttps://www.blogger.com/profile/12699829364867055077noreply@blogger.comtag:blogger.com,1999:blog-4833628955058077617.post-12581573096764083002020-02-14T22:48:58.739-05:002020-02-14T22:48:58.739-05:00(And for some weird reason, Blogger doesn't le...(And for some weird reason, Blogger doesn't let me have hyperlinks in the comments, so if you want to check out those links, just copy & paste into your browser.)Tuit Nutritionhttps://www.blogger.com/profile/15708859914305178756noreply@blogger.comtag:blogger.com,1999:blog-4833628955058077617.post-25470719777100121792020-02-14T22:48:17.598-05:002020-02-14T22:48:17.598-05:00Hi Kim. Actually, I've already written about t...Hi Kim. Actually, I've already written about the carnivore diet approach. Not for my own blog, but for someone else's site. See here: https://ketodietapp.com/Blog/lchf/what-is-the-carnivore-diet-potential-benefits-and-concerns<br /><br />As for the other issues - especially the metabolic processes, I'm going to be doing a series of videos on YouTube for "Keto 101" on my channel. Will probably start in a couple of weeks. In the meantime, you can see my other videos here: https://www.youtube.com/channel/UCmDz-SYYhoerycynsCm7L8g/videosTuit Nutritionhttps://www.blogger.com/profile/15708859914305178756noreply@blogger.comtag:blogger.com,1999:blog-4833628955058077617.post-21579923308532162712020-02-13T10:21:29.091-05:002020-02-13T10:21:29.091-05:00Amy, please consider an article on the Carnivore D...Amy, please consider an article on the Carnivore Diet, how weight happens, metabolic processes involved with this woe, etc. I am a medical,professional and appreciate your attention to detail and science based articles. Thank you!Kimhttps://www.blogger.com/profile/07525668690833585000noreply@blogger.comtag:blogger.com,1999:blog-4833628955058077617.post-18131003602934495252020-02-13T10:19:33.669-05:002020-02-13T10:19:33.669-05:00Love this site! As a medical professional, I desir...Love this site! As a medical professional, I desire scientifically based articles. Please consider doing an article on the Carnivore Diet, reasons for gaining weight on this diet and all metabolic processes while adjusting to this woe. Thank you, Amy, for contributing to this space of better eating and health. Thank you. Kim Alexander, CRNAKimhttps://www.blogger.com/profile/07525668690833585000noreply@blogger.comtag:blogger.com,1999:blog-4833628955058077617.post-22892700332072824302020-01-13T22:47:21.463-05:002020-01-13T22:47:21.463-05:00Hmmm...good question. I don't think your "...Hmmm...good question. I don't think your "personal fat threshold" would change, but if you put on more muscle mass, your insulin sensitivity and glucose tolerance likely would change for the better. Basically, your fat storage capacity might not change, but your ability to handle various metabolic fuels would probably improve. (I can't say for certain, though. But we see this in people who were formerly diabetic and who made major changes in their lifestyle and to their physique -- and they can tolerate more carbs than they could in the past. Not *a ton,* but they don't need to live in strict ketosis all the time. They can be a bit more flexible with carbs and still maintain good bloodwork/biomarkers.)Tuit Nutritionhttps://www.blogger.com/profile/15708859914305178756noreply@blogger.comtag:blogger.com,1999:blog-4833628955058077617.post-21186210186996538552020-01-13T19:09:26.905-05:002020-01-13T19:09:26.905-05:00Thank you for a very insightful article on the PFT...Thank you for a very insightful article on the PFT. I am one of those with a pretty normal BMI but has become pre-diabetic in my early 30s and feel my low PFT could be a reason. Do you have any thoughts on how the personal fat threshold change with the overall body weight or lean muscle mass? If i increase my muscle mass (along with some fat) with regular strength training would my PFT increase or stay the same? Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-4833628955058077617.post-66709462642857208292020-01-12T12:33:17.588-05:002020-01-12T12:33:17.588-05:00This is such a great post. I have an unusual circ...This is such a great post. I have an unusual circumstance where full body radiation exposure as a child (for AML) has caused permanent physiological changes in (at least) my subcutaneous adipocytes. These changes are partly related to the adipokines and the result is an altered fat threshold that resembles lipodystrophy (even though it isn't technically). I've been part of studies to figure this out at Rockefeller University in NYC where they actually harvested fat through a liposuction-like procedure. I'm very lean but have fasting triglycerides of over 500, even with extreme carb restriction and exercise factored in. Keto "helps" with some of my cholesterol numbers, but the fasting fat load in the blood is always maintained or elevated to over 1000 or more unless I remove fat from the diet. In the absence of fat in the diet, I process and use glucose very easily as my visceral fat melts away and my blood levels ramp down. If my triglycerides level is high though, because of the amount of fat I am eating, I will always see hyperinsulinemia, hyperuricemia, high homocysteine (not affected by any methylation protocol), hypertension, kidney impairment and hyperglycemia. I actually love being LCHF, but it makes my situation worse because even when fat adapted, I can't burn fat off quickly enough to offset the intake...or at least I haven't found a ratio of macros or a fat intake portfolio (which focuses on particular types of fat over others) that does the trick aside from simply cutting almost all fat. This includes incorporating pretty extreme fasting and/or TRF protocols. What I do know, is that most plant oils, MCTs, and other saturated fats (including coconut oil and other short chain sat fats) worsen my cholesterol profile (Apo-B and LDL-P ) dramatically, in addition to keeping my triglycerides elevated. I'll be following this site as well as Ted Naiman's stuff.. Thanks again!The_Professorhttps://www.blogger.com/profile/01727397126015325359noreply@blogger.comtag:blogger.com,1999:blog-4833628955058077617.post-41541903022147934562020-01-03T17:28:34.386-05:002020-01-03T17:28:34.386-05:00Please send me an email -- I have some thoughts fo...Please send me an email -- I have some thoughts for you. You can just copy & paste this into an email to me, or tell me you're the one who commented on this post and have questions regarding a safe diet for *not* losing weight while managing/improving prediabetes. <br />Address is: tuitnutrition@gmail.comTuit Nutritionhttps://www.blogger.com/profile/15708859914305178756noreply@blogger.comtag:blogger.com,1999:blog-4833628955058077617.post-11195832974773743702020-01-03T10:43:03.143-05:002020-01-03T10:43:03.143-05:00Hi. This is very interesting reading. I am strug...Hi. This is very interesting reading. I am struggling as someone who is underweight with low BMI and fluctuating between pre-diabetic and diabetic readings to know what a safe diet is for me - I simply cannot afford to lose any weight as I am at risk of osteoporosis etc. I can't find any information for underweight diabetics. Please can anyone help?Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-4833628955058077617.post-48232821985408871172019-05-21T21:47:55.470-04:002019-05-21T21:47:55.470-04:00Seems almost impossible that you've lost 30 po...Seems almost impossible that you've lost 30 pounds and NONE of it is fat. How are you assessing that? What kind of body composition testing are you doing that has led you to that conclusion? Only visual and your clothing? Consider paying for a DEXA scan. Your self-assessment sounds like you are probably guessing wrong. Tuit Nutritionhttps://www.blogger.com/profile/15708859914305178756noreply@blogger.comtag:blogger.com,1999:blog-4833628955058077617.post-4404001027881001862019-05-21T20:13:41.642-04:002019-05-21T20:13:41.642-04:00Hi, just came across your blog. I have been doing ...Hi, just came across your blog. I have been doing a keto diet for just over 3 months. I have lost roughly 30 lbs but have not had any fat loss. I measure weekly, no change. No change in how my clothes fit. No visual change in body composition. Fat loss is my goal snd not the scale per se. Am I not fat adapted? I fast and don't feel hungry. I read your post about fat adaptation vs ketosis, and fat adaptation that leads to fat loss is my objective. Any thoughts?Anonymoushttps://www.blogger.com/profile/07947728922278796567noreply@blogger.comtag:blogger.com,1999:blog-4833628955058077617.post-77549257689359450332019-04-17T10:03:05.097-04:002019-04-17T10:03:05.097-04:00The point is that T2D is a dietary condition and a...The point is that T2D is a dietary condition and as such, it has a dietary solution. If carbs gave you T2D in the first place, of course you will not be able to eat them ever in the future and not have your T2D returning. The point of the "reversal" of T2D is not so one can eat once again their beloved carbs, but so that they can avoid all the health complications of diabetes.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-4833628955058077617.post-89991870147344031462019-04-05T23:23:45.771-04:002019-04-05T23:23:45.771-04:00Hey Gary, thanks for reading. As much as I love th...Hey Gary, thanks for reading. As much as I love the fasting insulin test, it's not a slam-dunk. Just like with fasting glucose, fasting insulin can be elevated for a few different reasons and a high-ish fasting insulin isn't automatically indicative of anything bad going on. If it was only measured once and it was high, I wouldn't worry that much (or at all), especially if you're having success on low carb. Sounds like your insulin is regularly low enough for you to have lost some weight, so if you're talking about having your insulin tested *one* time and it was a little high, it might have just been a fluke the one time. <br /><br />I know some low carb/keto MDs who don't like the fasting insulin test and don't think it's all that reliable. I can see why -- like I said, it can be elevated for reasons that have nothing to do with a metabolic problem. So don't put 100% faith in it, but I still think it's worth having done every time you get a checkup or have routine bloodwork done. Tuit Nutritionhttps://www.blogger.com/profile/15708859914305178756noreply@blogger.comtag:blogger.com,1999:blog-4833628955058077617.post-22993680352193846432019-04-05T12:06:51.057-04:002019-04-05T12:06:51.057-04:00Amy - I'm curious if you've ever encounter...Amy - I'm curious if you've ever encountered, or had any thoughts on the following...Your post noted many people have significant improvements in T2D or insulin levels BEFORE any weight loss...I've experienced weight loss (6' - 170lbs) but fasting insulin levels have remained quite high. I don't measure ketones but manage to a very low-carb, HF diet. Thoughts on why fasting insulin would remain stubbornly high?Garynoreply@blogger.comtag:blogger.com,1999:blog-4833628955058077617.post-67268762811474921462019-03-20T16:14:25.704-04:002019-03-20T16:14:25.704-04:00Always wonder why there is "HF" addition...Always wonder why there is "HF" addition. For the adaptation phaze thats ok. But after it...?)) People need to burn their own stuff, but instead they continue loading themselves with tons of fatty food. "Counting calories - the stupidest thing ever" a video of one MD is labeled. Hasn't answered for the question "Ok, if I can eat a 4-5k kcal daily? yet)Anonymoushttps://www.blogger.com/profile/06800052848101983683noreply@blogger.comtag:blogger.com,1999:blog-4833628955058077617.post-24455932580217954322019-01-28T14:33:30.621-05:002019-01-28T14:33:30.621-05:00Amy was implying that the cause of the insulin/sug...Amy was implying that the cause of the insulin/sugar disregulation was the fat in the pancreas/liver - not the loss of beta cells, and that it goes first when you start losing weight, thus reverting T2D - that's what I don't really agree with.Ventsyslav Raikovhttps://www.blogger.com/profile/00242179635818764321noreply@blogger.comtag:blogger.com,1999:blog-4833628955058077617.post-31361861053258507272019-01-27T16:41:39.907-05:002019-01-27T16:41:39.907-05:00But why would you want or need to eat sugar and fr...But why would you want or need to eat sugar and fruit?<br /><br />Here's a clue, you can greatly reduce your insulin resistance, thus the insulin you still produce can go much further. Regrowing beta cells, there's the problem. Theoretically by the time you are diagnosed with diabetes you have lost 50% of your beta cells. A high carb low fat diet will NOT help. As can be seen by the outcomes of conventional diabetes treatment, it invariably causes the disease to progress.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-4833628955058077617.post-53455006392638750882019-01-27T04:03:13.344-05:002019-01-27T04:03:13.344-05:00Too much LCHF/keto bias and nuance in this post.
&...Too much LCHF/keto bias and nuance in this post.<br />"burn fat, eat fat" and "burn carbs, eat carbs" nothing is black and white in biology - we always burn both glucose AND fat, in different ratios of course.<br />I haven't seen a single case of going LCHF/keto and really reversing T2D - which means being able to actually eat sugar/fruit and have a normal glucose and hormonal response. Avoiding carbs and saying that you've reversed T2D is like staying still with a torn meniscus and saying that you're cured.Ventsyslav Raikovhttps://www.blogger.com/profile/00242179635818764321noreply@blogger.comtag:blogger.com,1999:blog-4833628955058077617.post-30569901064253571812019-01-26T17:09:27.451-05:002019-01-26T17:09:27.451-05:00You may dont like the term "Insulin resistanc...You may dont like the term "Insulin resistance" because you dont understand how to measure it. Using hyperinsulinaemic‐euglycaemic glucose clamp you can get direct value of IR. In addition you can also use Krafts test to measure the pattern of the insulin and glucose and from that to see IR.<br />Hyperinsulinemia doent correlates very well with the gold standard (hyperinsulinaemic‐euglycaemic glucose clamp) and its mostly shown as HOMA-IR which also does not correlate very well with the gold standard. You can also use steady state plasma glucose (SSPG) which is similar to the hyperinsulinaemic‐euglycaemic glucose clamp.<br /><br />Insulin resistance is real, measurable and correlates better to diseases than hyperinsulinemia Anonymoushttps://www.blogger.com/profile/15293751474446376305noreply@blogger.comtag:blogger.com,1999:blog-4833628955058077617.post-39758541142383874072019-01-25T12:07:04.939-05:002019-01-25T12:07:04.939-05:00Yes I see both your points. We need enough insulin...Yes I see both your points. We need enough insulin but no more than that, a knowledgeable Type 1 told me about 20 - 50 units/day is what an undamaged pancreas produces, depending on size, exercise levels etc. Many Type 2s are on huge quantities by comparison. Even some Type 1s who cover their(recommended) carbs with insulin use more than that. Probably one reason "double diabetes" - Type 1 with insulin resistance - has become commonplace, it used to be mainly caused by steroids or other drugs.Anonymousnoreply@blogger.com