tag:blogger.com,1999:blog-4833628955058077617.post3006281787428829371..comments2024-02-20T16:22:10.042-05:00Comments on Tuit Nutrition: A New Look at Insulin, Glucagon & the Pancreas (a.k.a. ITIS part 9) Amy B.http://www.blogger.com/profile/08471580967464668110noreply@blogger.comBlogger20125tag:blogger.com,1999:blog-4833628955058077617.post-66614152176825731362022-06-09T19:46:50.899-04:002022-06-09T19:46:50.899-04:00Amy - I love your writing (style and content) and ...Amy - I love your writing (style and content) and have read all of the "ITIS" series, as well as the PFT article. I have also read a lot of other explorations of the topic of diet, T2D, CVD, insulin, LDL-C, etc., etc., and am now left with a burning question: which matters more - diet (e.g., keto, low-carb, low-fat, DASH, Mediterranean, Ornish, Cornish, Danish, Kitavan (sorry, I did that on purpose)), or just keeping below one's PFT, regardless of diet? Is the entire fat vs. carbs debate largely moot, as long as whatever diet you are on keeps you below your PFT and keeps fat out of your pancreas? It increasingly seems as though that is the main thing: keep fat out of your pancreas for a long life. Whatever you have to do to get and stay below your PFT, do it now. The only problem is determining what one's Personal Fat Threshold might be...Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-4833628955058077617.post-74035903522957144392021-01-13T20:18:09.283-05:002021-01-13T20:18:09.283-05:00Ditto!!Ditto!!Anonymoushttps://www.blogger.com/profile/15414672003478996084noreply@blogger.comtag:blogger.com,1999:blog-4833628955058077617.post-24405685650439627422019-09-28T18:04:33.111-04:002019-09-28T18:04:33.111-04:00Fascinating. Loved every word. Do you know anythin...Fascinating. Loved every word. Do you know anything about the particular antibodies involved in T1D and how they may or may not behave differently? A lot of people have GAD antibodies, but then other have Zinc Transporter antibodies or Islet cell antibodies. I've always wondered if this makes a difference in what mechanisms are impaired specifically. But I haven't come across much if any research on the topic.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-4833628955058077617.post-82930518920322156082019-07-08T23:43:25.451-04:002019-07-08T23:43:25.451-04:00I'll throw this out there for someone smarter ...I'll throw this out there for someone smarter than me to consider. Reading this I just started to have this idea of the pancreatic fat playing a role in "beta cell burnout", in a more direct way ... perhaps by absorbing the insulin spike intended to inhibit glucagon.<br /><br />Several quotes from the article: <br /><br /><br />This means that, in addition to the transporters resident in the cell membrane at any given moment, there is a pool of glucose transporter molecules in the cytoplasm of the cell which can be recruited in response to a rise in plasma insulin, to join those already in the cell membrane in the fasting state.<br /><br />Pancreatic fat. T2D correlates with beta cell lipotoxicity.<br /><br />Well, if insulin is going to suppress release of glucagon, then the alpha cells have to be insulin sensitive. And it appears that this is not the case in type 2 diabetes.<br /><br />In T2D, alpha cells don’t respond to insulin the way a non-diabetic’s do. Glucagon is not suppressed as much per unit of insulin.<br /><br />You do the same experiment in pancreas isolated from type 2 diabetic animals and the first thing you note is that the dramatic spike in insulin is gone. BUT, insulin levels are higher than normal. Because the insulin spike is gone, it’s not surprising that there is no suppression of glucagon.<br /><br /><br />OK, so what if that insulin spike intended to inhibit glucagon is instead is utilized to "recruit glucose transport molecules" in the pancreatic fat. It didn't need to do that, but it was there, and it reacted how it should to insulin ... it utilized it.<br /><br />In doing so, the spike never got to the alpha cells. The other insulin levels are high, sure, certainly some insulin will get past the pancreatic fat after they've used what they could. But the spike to shut down glucagon was thwarted.<br /><br />Loose fat, especially pancreatic fat, and the process starts to work again.Melnoreply@blogger.comtag:blogger.com,1999:blog-4833628955058077617.post-9646602335919302292019-06-08T13:15:12.998-04:002019-06-08T13:15:12.998-04:00Thanks so much! I'm glad my work has been help...Thanks so much! I'm glad my work has been helpful. I'm starting to see my role more and more as *simplifying* things and helping people to see how UN-complicated and straightforward this all is, when they take away all the unnecessary details & minutiae. Tuit Nutritionhttps://www.blogger.com/profile/15708859914305178756noreply@blogger.comtag:blogger.com,1999:blog-4833628955058077617.post-26944542269510332902019-06-03T15:41:27.610-04:002019-06-03T15:41:27.610-04:00I just want to tell you how much I am enjoying thi...I just want to tell you how much I am enjoying this blog, and also, how much I am enjoying your book the Alzheimers Antidote. This disease runs in my family, so I am looking for ways to prevent it. An unexpected, wonderful surprise in this book were the recommendations of just eating low carb without counting. I just can't do the numbers game all day long. Now I know how to eat, what to eat and what not to eat, and I am grateful. Simple. No adding up carb grams, macros, etc. It reminds me of the South Beach diet I used to follow without all the low fat nonsense. Thank you. Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-4833628955058077617.post-34022496461820923462019-05-18T08:19:53.374-04:002019-05-18T08:19:53.374-04:00Thanks for the great post. Lots of it went over m...Thanks for the great post. Lots of it went over my head, it is not the lightest of reads. I was going to go on Metformin, luckily, I discover Dr Fung’s book, and started low carb and intermittent fasting. Now I am feeling much better, i enjoyed watching your video on YouTube followed the link to your site. Thank you for getting the info out. I find very few older T2D people willing to change, like they are following this injection protocol, their doctor said it was ok, so it’s got to be ok. They are like galvanised not to change, I find this behaviour very interesting. So getting good info out that is explainable others might persuade some to question their current treatments, and change their diets and improve their lives.newoptionzhttps://www.blogger.com/profile/00914818010610870940noreply@blogger.comtag:blogger.com,1999:blog-4833628955058077617.post-40925827612989518102019-04-04T17:13:57.841-04:002019-04-04T17:13:57.841-04:00It is so refreshing to see someone write about how...It is so refreshing to see someone write about how the more they learn the less they know. This is how I feel most of the time. How lucky are we you are still learning and sharing you information? Thank you for that. You are providing very helpful information, especially for those of us who are trying to regain our health and have a long, healthy life. <br />Anonymoushttps://www.blogger.com/profile/01652542954303255657noreply@blogger.comtag:blogger.com,1999:blog-4833628955058077617.post-25266263421315163792019-03-27T18:34:25.485-04:002019-03-27T18:34:25.485-04:00This post was amazing!! Keep up the long form (as ...This post was amazing!! Keep up the long form (as you are inspired to do so!). I love all the data and primary source citations embedded. As a research scientist I appreciate all the time to find, read, write about, and cite this wealth of knowledge! You are a rock star! Thank you for caring enough to make the effort to publish these extensive posts!! Heading over to Patreon now! :D Neuroknitterhttps://www.blogger.com/profile/14193459083871831563noreply@blogger.comtag:blogger.com,1999:blog-4833628955058077617.post-51067441437084971662019-03-24T09:36:17.373-04:002019-03-24T09:36:17.373-04:00Just because I link to something doesn't mean ...Just because I link to something doesn't mean I agree with everything the author has ever said or written. I've met Dr. Feinman a few times in person and he's a good guy. But I disagree about sugar addiction.l It can absolutely be devastating in many ways, and not just to health. I would definitely classify sugar as a "real" addiction. Hard to comprehend if one has never experienced it, just like compulsive overeating, binge eating, and *any* food addiction, for that matter. Tuit Nutritionhttps://www.blogger.com/profile/15708859914305178756noreply@blogger.comtag:blogger.com,1999:blog-4833628955058077617.post-21159973018794996362019-03-24T08:18:48.985-04:002019-03-24T08:18:48.985-04:00RE: " _World Turned Upside Down" the aut...RE: " _World Turned Upside Down" the author states that calling sugar addiction trivializes real addictions like alcohol, and other hard drugs — kidney failure, blindness, amputations et al. are _really serious_. Dr. Lustig says the long term metabolic consequences of sugar and alcohol are the same.Thomashttps://www.blogger.com/profile/18387187936598791801noreply@blogger.comtag:blogger.com,1999:blog-4833628955058077617.post-35026203005462412472019-03-22T20:16:29.755-04:002019-03-22T20:16:29.755-04:00Thanks for reading. I don't know which it is. ...Thanks for reading. I don't know which it is. Maybe both. But I have a hard time believing that most people with T2D have beta cell "burnout." If you measure their insulin, it's usually still sky high, so they are still pumping out of plenty of insulin. There might be a very end-stage kind of thing where the cells actually atrophy or die and are not able to pump out inordinate amounts of insulin, but I think to actually test this is very rare. It would be C-peptide, and it's hardly ever ordered in T2 diabetics. (They use it with T1D to see if someone is still producing any of their own insulin.) I'm honestly not sure of the answers here, though. It could be both -- beta cells not secreting enough insulin, *and* localized "resistance" (hate that word) at the level of the alpha cell. *Shrug.*Tuit Nutritionhttps://www.blogger.com/profile/15708859914305178756noreply@blogger.comtag:blogger.com,1999:blog-4833628955058077617.post-64355574883260728762019-03-22T18:43:08.527-04:002019-03-22T18:43:08.527-04:00Excellent post! Content like this is sorely neede...Excellent post! Content like this is sorely needed. I need to pour over the references, they look fascinating.<br /><br />Question: At one point there's discussion about fat in the pancreas causing issues between the alpha and beta cells. Then later there's a bit about either the beta cells burning out and not putting out enough local insulin or the alpha cells being resistant to the insulin.<br /><br />Any thoughts on which it is? Or a combination of both? Or have I misread these parts?<br /><br />Thanks,<br />John<br />Unknownhttps://www.blogger.com/profile/16863962246443471593noreply@blogger.comtag:blogger.com,1999:blog-4833628955058077617.post-49534333170877170832019-03-21T16:13:41.728-04:002019-03-21T16:13:41.728-04:00I know approximately zero about pancreatitis, so I...I know approximately zero about pancreatitis, so I can't write about it right now, but if I had to take a wild guess, it's probably the same story with kidney function -- higher protein is probably fine, because I would imagine it's sugar (glucose/fructose) that does the most damage, not amino acids. But I can't write on it at the moment. Maybe sometime down the line. Tuit Nutritionhttps://www.blogger.com/profile/15708859914305178756noreply@blogger.comtag:blogger.com,1999:blog-4833628955058077617.post-34126951156115018232019-03-21T16:12:27.811-04:002019-03-21T16:12:27.811-04:00Thanks for writing. Yes, far too much fearmongerin...Thanks for writing. Yes, far too much fearmongering about protein in the keto world, although I like a lot of Carl & Richard's work, so I'll keep silent on that particular issue. I think they both understand that different things work for different people and they generally don't give blanket recommendations for "everyone."Tuit Nutritionhttps://www.blogger.com/profile/15708859914305178756noreply@blogger.comtag:blogger.com,1999:blog-4833628955058077617.post-64469025164346977882019-03-21T11:43:48.942-04:002019-03-21T11:43:48.942-04:00It makes logical sense to me that placing less &qu...It makes logical sense to me that placing less "pressure" on the pancreas would be better for pancreatitis. Thus, I would think keto could would well. Furthermore, if the pancreatitis is caused at all by extra fat, intermittent or longer term fasting should help. See, eg:<br /><br />https://idmprogram.com/fatty-pancreas-t2d34/<br /><br />https://idmprogram.com/fatty-pancreas-t2d-9/<br /><br />If you're specifically looking at T2 diabetics, and they're taking drugs including insulin, you have to do this under supervision, as drug requirements can plummet. ctviggenhttps://www.blogger.com/profile/06768434099612988952noreply@blogger.comtag:blogger.com,1999:blog-4833628955058077617.post-67948353879145643192019-03-20T12:21:21.008-04:002019-03-20T12:21:21.008-04:00Great, thank you Amy!
Would you be interested to ...Great, thank you Amy!<br /><br />Would you be interested to tackle nutrition in pancreatitis in T2Ds? The big three (Chris, Robb, and Mark) do not have specific posts about this condition, only forums or comments. General advice is low-fat, high fiber. With quick googling, only Dr. Dahlman recommends keto.Noorahttps://www.blogger.com/profile/08405502694383018990noreply@blogger.comtag:blogger.com,1999:blog-4833628955058077617.post-28609239083675635802019-03-20T11:16:36.924-04:002019-03-20T11:16:36.924-04:00I'm glad you're a voice of reason in the l...I'm glad you're a voice of reason in the low carb/keto community. I bought a continuous glucose monitor to test what happened to my blood sugar when eating protein. I was convinced I'd find a massive blood sugar rise when eating 80+, 120+, 160+ grams of protein in a single meal. What did I find? Nothing. My blood sugar seems unaffected by the proteins I was eating (from real food, not isolated in cans). Moreover, I felt better. So, now, I eat a higher protein and lower fat keto diet, and my HbA1c has continued to decrease. <br /><br />There are still locations on the 'Net where keto people are terrified of protein. The 2 Keto Dudes forum is one of them. ctviggenhttps://www.blogger.com/profile/06768434099612988952noreply@blogger.comtag:blogger.com,1999:blog-4833628955058077617.post-59466686852777061922019-03-20T10:23:50.346-04:002019-03-20T10:23:50.346-04:00Okay… I have to echo Robin's comments. I love ...Okay… I have to echo Robin's comments. I love the way you write and one can never tell when one "geeks out" on material where you will find a nugget of understanding or at least avoid misunderstanding something important. Clearly I'm going to have to come back to this blog post and spend a little time "studying" and going back to look at some of the other references that you so kindly pointed my nose too. Just when I thought I could go read some lazy novel… Something interesting comes my way. I don't know if you have thought about another book… But perhaps a translation book between dieting and physiology… And possible practical implications (there is always that strange issue of fasting and autophagy and its related cell death which I can't spell). You might take on the persona of Isaac Asimov who wrote some "popular" science books in addition to his science fiction… Something along the lines of "The Human Body: Its Structure and<br />Operation" only more focused and related to low-carb and diet in general. In any event thank you again for the delightful blog post and I will get back to it and watch the videos and read the papers and put my novel aside for a little while. I never thought that when I wanted to figure out how to lose weight I would get sucked up into human physiology as well. LittleJoehttps://www.blogger.com/profile/13823323991360520857noreply@blogger.comtag:blogger.com,1999:blog-4833628955058077617.post-87031025567009844512019-03-20T08:05:58.564-04:002019-03-20T08:05:58.564-04:00I scrolled to the end. Read End and thought, "...I scrolled to the end. Read End and thought, "there is no way I want to read 8000 words on insulin." But started on it anyway and could NOT PULL MYSELF AWAY. This was riveting. Thanks. And super glad you are on Patreon. robinhttps://www.blogger.com/profile/12429999944410397065noreply@blogger.com